Benefical Effects of Sigma-1 Agonist Fluvoxamine for Tardive Dyskinesia and Tardive Akathisia in Patients with Schizophrenia: Report of Three Cases
نویسندگان
چکیده
Fluvoxamine is a selective serotonin reuptake inhibitor that is approved for psychiatric disorders such as major depressive episodes and obsessive-compulsive disorder. Beside inhibition of serotonin reuptake, fluvoxamine is also a potent agonist of endoplasmic reticulum (ER) protein sigma-1 receptors, which play a role in the pathophysiology of a number of psychiatric and neurodegenerative disorders. This report presents beneficial effects of sigma-1 agonist fluvoxamine on hyperkinetic movement disorders such as tardive dyskinesia and tardive akathisia. Fluvoxamine might be a novel treatmet approach in the treatment of hyperkinetic movement disorders.
منابع مشابه
An investigation on the relationship between risk factors and severity of tardive dyskinesia
The focus of most previous research concerning tardive dyskinesia has been on the impact of risk factors on the development( incidence) of this syndrome. In this paper, we report our results on the relationship between risk factors and the severity of tardive dyskinesia. A total of 33 patients diagnosed as tardive dyskinesia with no other medical illness studied: 21 males and 12 females with a ...
متن کاملThe inter-relationships of tardive dyskinesia, parkinsonism, akathisia and tardive dystonia: the Curaçao Extrapyramidal Syndromes Study II.
A study of the four extrapyramidal syndromes (EPS), tardive dyskinesia, parkinsonism, akathisia and tardive dystonia, was performed in the Netherlands Antilles, a well-defined catchment area with only one psychiatric hospital. The population under study (N = 194; mean age 53.1) was mainly Afro-Caribbean, and most patients were chronic. The severity of each EPS was measured with valid and reliab...
متن کاملOxidative stress and tardive dyskinesia: role of natural antioxidants
Schizophrenia is a devastating psychiatric disorder that affects 1% of population worldwide. Neuroleptics are the major class of drugs used in the treatment of schizophrenia. Neuroleptics are associated with wide variety of extrapyramidal side effects such as akathesia, dystonia, neuroleptic malignant syndrome, Parkinsonism and tardive dyskinesia. tardive dyskinesia is a complex hyperkinetic sy...
متن کاملOxidative stress and tardive dyskinesia: role of natural antioxidants
Schizophrenia is a devastating psychiatric disorder that affects 1% of population worldwide. Neuroleptics are the major class of drugs used in the treatment of schizophrenia. Neuroleptics are associated with wide variety of extrapyramidal side effects such as akathesia, dystonia, neuroleptic malignant syndrome, Parkinsonism and tardive dyskinesia. tardive dyskinesia is a complex hyperkinetic sy...
متن کاملFluvoxamine for blonanserin-associated akathisia in patients with schizophrenia: report of five cases
BACKGROUND Atypical antipsychotic drugs have been reported to cause fewer incidences of extrapyramidal side effects (EPS) than typical antipsychotic drugs, but adverse events such as akathisia have been observed even with atypical antipsychotic drugs. Although understanding of the pathophysiology of akathisia remains limited, it seems that a complex interaction of several neurotransmitter syste...
متن کامل